A protein which exhibits a therapeutic effect on inflammation and is useful for treating IL-1-mediated inflammatory diseases, particularly diseases of the joint. The charge pump is in fluid communication with the main hydraulic unit for maintaining a sufficient inlet pressure in the main hydraulic unit when it functions as the pump. A gate pattern is provided on the charge storage pattern. Then, the dielectric material on the top of the protruding structure and on portions of the substrate is removed to form an L-shaped spacer. If desired, the filter-captured aggregates are subject to a brief washing cycle where they are washed clean of residual aggregating agent, plasma, and red cells.