The invention relates to the chemically modified genomic sequence of the human C-mos gene, to oligonucleotides andor PNA oligomers directed against the sequence for detecting the cytosine methylation condition of the human C-mos gene and to a method for determining genetic andor epigenetic parameters of the human C-mos gene. Preferably computer-controlled, the apparatus follows the method of the invention to produce the workpiece by radiation and compacting of nx successive layers of powdered starting material, each subsequent layer being formed on the uppermost surface of the previously formed layer. The control unit detects the alignment mark and the circumferential edge based on the luminance distribution pattern. The roll seal may also include a toe portion that engages the developer frame to resist movement of the roll seal when the developer roll rotates against the roll seal. The process formed a calcined body that has excellent strength and can be handled easily.