A catheter die is provided and includes a device layer defining a cavity and including a piezoresistive pressure sensor operably disposed proximate to the cavity and an insulator having an opening and being disposed on an upper surface of the device layer such that a portion of the piezoresistive pressure sensor is exposed through the opening. More particularly, this invention provides the synthesis of indirubin derivative known as CDK inhibitor. The authentication module is configured to perform authentication of the source device based on authentication data. 1 channel audio signal through a 2-channel headphone.