A low resistance air filter device comprises a tubular case for at least a filtering element fixed to a lower opening of the case. During each phase of the process, the mixed liquor in at least one of the basins is subject to settling. The facility provides for storing measurement data associated with a single IO operation in an extended measurement word associated with an IO response block. The message defines the desired rate constraint and the number voice frames to be constrained. The conjugates according to the present invention have a structure according to the following formula HAS\u2032n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS\u2032 is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight above the renal threshold.