Systems and methods may provide for conducting a region determination of whether one or more domain points associated with a tessellated patch are shared between multiple region sets of the tessellated patch. The methods comprise a compound having a pharmacological selectivity of serotonin norepinephrine of at least about 5000. As a result, a plurality of Web pages are continuously reproduced and output at predetermined time intervals. Each input of the serializer comprises one bit of an N-bit-wide parallel input bus, and the data rate of the serializer output matches the data rate of the high-speed channel.