An e-mail based content import system imports content into a content management system using an e-mail application. A search function can default to a search of all email contexts, thereby eliminating user cogitation over which context an email message may be stored in. The preformed holders may be positioned on the bottom of the estuary or broadcast on the surface. Also provided are methods for the treatment or prophylaxis of inflammatory and autoimmune disorders in a mammal by administering compounds of the invention. Because the tandem free operation mode is impossible in the case of a coding mode that is unauthorized for that operation mode, instead of using a tandem operation mode in this case, the tandem free operation mode is used, if possible, with an authorized coding mode, provided that the authorized coding mode is supported.