The inventor found that the lightwave of a semiconductor laser includes, in addition to the laser oscillation lightwave, a weak, continuous noise component having a different wavelength. The micro-needle has a structure having a base at a proximal end and a vertex at a distal end, and an open lumen extending there through and through which fluid may be transferred. The second substrate has a second conductive layer, and a plurality of second electrodes that extend form both ends of the second conductive layer and that have second electrode lead sections. The upper pull tab section has a liner material portion cut out to adhere to a back or under side of the upper tab section upon pulling the label off the liner material for use. Also provided are tumoricidal T cells and NKT cells devoid of inhibitory receptors or inhibitory signaling motifs which are hyperresponsive to the the above compositions and lipid-based tumor associated antigens that can be administered for adoptive immunotherapy of cancer and infectious diseases. The controller may be configured to receive a signal from the speaker, the signal induced at least in part by sound incident on the speaker other than sound generated by the speaker and process the signal.