The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. If the program reference address lies with the prefetch region, an offset distance is used to determine the address of the prefetch block. In a multi-level cell architecture where two or more bits may be stored in a single cell, memory address translation circuitry may translate data to be stored in low-density mode. The interface determines a provider process that can make the requested change, and forwards the request to the provider process. A shroud member encloses the upper and lower frame support members and is fastened to the table member and includes thereon a manually manipulatable handle movable between first and second positions, the handle including a link interconnecting the handle and the lock release mechanism. Methods for preparation of graphite oxide are also disclosed.