The disclosure provides methods of preventing or treating heart failure in a mammalian subject. In order to secure the reliability by controlling the IC temperature below a predetermined level, the difference in the IC cooling ability varying with the radial position on the disk is quantified, so that power sufficient to maintain a constant temperature according to the IC temperature is supplied to the IC. The pedal unit includes a support plate, an actuating pedal coupled to the support plate, a shock-absorbing hinge, and a coupling hinge. The powder-filled container is placed in a metal vessel and surrounded with glass frit. This eliminates the step of printing a separate adhesive-backed indexing image sheet and applying it to the substrate. In addition, the machine can operate in the first and second cycles simultaneously.