The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers. The alloys have high strength and ductility. The connection elements are positioned between and connected to two adjacent column elements. The pressure applying assembly includes an adjustment mechanism for forcing one pad assembly towards the other in a continuously adjustable, controlled manner creating a compression of the ear tissues required for proper healing between the two opposing pads. Importantly, the photoresist is variably exposed so that when developed some of the resist layer remains.