In a method to determine an inversion time value for contrast improvement between different tissue in a contrast agent-supported magnetic resonance imaging, a series of magnetic resonance images of an imaging area is acquired using an inversion recovery sequence with different inversion times. The object of the invention is to find ways by which medication can be administered to a patient with a high degree of accuracy. The concentration of the nucleotide synthesis inhibitor in the blood of the mammal is observed and it is determined whether the nucleotide synthesis inhibitor has a half-life which is shorter than that of N–2-cyano-3-hydroxycrotonamide. The preferred applicator impacts the stratum corneum with the microprotrusion member with an impact of at least 0. The data compression arrangement may include a data compression unit at the transmitting side of the communication interface, and a data decompression unit at the receiving side of the communication interface. The encapsulation unit may include a first region corresponding to the light emitting unit and a second region coalesced with the substrate.