An object is to provide a programmable logic device having logic blocks connected to each other by a programmable switch, where the programmable switch is characterized by an oxide semiconductor transistor incorporated therein. A counterbore on the backing plate improves stress isolation properties of the sensor. The hub assembly is rotatably coupled to the sprocket and structured to rotate in a charging direction relative to the sprocket. A ring rotation mechanism rotates the supply ring and winding ring in the same direction as that in which the supply ring was rotated when being loaded with the wire, but at mutually different speeds, to wind the wire around the toroidal core. Peak area integration of the peptide pairs provides a direct measure for the amount of target protein in the crude solution.