A low profile, short, tapered distal tip catheter and methods for its manufacture are provided. A heat exchanger can transfer heat between a heat-exchange fluid flowing through flow paths and a fluid with which heat is to be exchanged flowing through other flow paths by means of the flow path structure member and a second metal sheet ) in which the flow paths are formed. Secondly it discusses how to stop any piece of equipment completely. The network pages facilitate a selection of at least one of products depicted in the images to be considered for purchase. The surface area of the collection membrane matches the view field of a standard imaging system and the device can be mounted on a standard microscope stage.