N–sulfonamides of general formula :are useful in the treatment of spinal cord injury. The subsea wellhead assembly comprises a tubing head structure with a tree above the tubing head structure, and a recoverable module attached to the tubing head structure below said tree, the recoverable module comprising at least one valve and at least one sensor. The heat bondable plastic material is preferably a polymeric or composite material suitable for surgical applications and implantation in humans, and may be a biodegradable material. The first order correction estimates the derivative using the current amplitude corrected sample and at least one additional amplitude corrected sample. The system detects a face zone of a captured image and locates an eye area in the face zone then calculating a ratio of height and width of the eye area and compares the ratio to the second threshold value.