An endoscopic bipolar forceps includes an elongated shaft having opposing jaw members at a distal end thereof. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing NPM-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an NPM-1 gene has been introduced or disrupted. 1 to 50 nanoseconds, and an exposure energy dose of from 0. Magnitudes of the three rotational components are quantified by image correlation and the positional displacement corrected. Filters include the use of a scoring scheme, comparison of scan numbers versus sequence of common ions to be MSMS, and daughter ion subtraction for obtaining pattern match candidates.