In one aspect, the disclosure is related to a seal for a gear case. The computing device detects a first input by a user on a destination object displayed on the touch screen display. Different selectivity estimating approaches are used for each group size based on available time for estimating and on the estimated time to complete the estimate using different techniques. In one aspect of the invention a high mobility silicon layer can be provided by crystallizing an amorphous silicon layer. Central speakers are arranged at the focal point of the spherical screen, so that viewers perceive the sound effect as coming directly from the spherical screen. Methods for generating the capture agents, tagged protein libraries and samples are also provided.