Systems, devices and methods are provided for endoscopic procedures involving tissue manipulations beyond the capabilities of traditional endoscopic instruments. A normal information generating device captures the image of the subject and thereby passively generates normal information on the surface of the subject. The conversion includes striping the received signal into virtual lanes and segmenting the lanes into packets. A fiber feed tube is centered on the interior of the die. In the cache bypass mode the power supply to a cache memory is switched off to reduce power consumption. The invention provides a method for reducing or preventing an inflammation comprising subjecting a mammal to a treatment with at least one inhibitor which is capable of inhibiting proteolytic activity.