A holder support device in an electron microscope. The difference between an AC impedance measured at a specific frequency and at a specific skin area with calibration electrode and a reference electrode and the impedance measured at a similar frequency and in the same area with a measurement electrode and a reference electrode, is used to determine the state of health of the internal organ corresponding to the examined skin area. The first framework object includes a first set of data values and a set of structure data defining at least one dimension for formatting the first set of data values.