A distal protection device that may include a guidewire having a proximal end and a distal end, a filter disposed on the guidewire, the filter including filtering material and an expandable hollow coil, and a wire at least partially disposed within the coil, wherein the filter is actuatable from a closed position to an open position by reducing tension on the wire and methods of use thereof. Thus, an astigmatic focus servo free from effects of variations in a focus error signal due to the interference fringe is realized. The inventive measured value acquisition and processing unit separately acquires these interfering portions by means of a switch element disposed in the area of feed of the measured signals by means of which the measuring circuit is short circuited in such a manner that the measured signal is not coupled in but only interfering signals that might occur in the measuring circuit are detected. The upper end of the upper column section forms a sleeve into which a deep heel truss is set. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of SULF are provided. The compositions comprise functionalized silicones having defined physicochemical properties that exhibit superior conditioning duability on hair than previously known silicone based conditioners, especially where the hair has been previously damaged through chemical treatments, such as occurs during permanent dyeing, bleaching and permanent waving.