The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing Juvenile Renal Dysplasia or calcium oxalate stones. The driver circuit also generates another two control signals that change from high to low as the input signal changes from high to low, and change from low to high as the input signal changes from low to high. The excitation signal which results in a minimum error between the target signal and synthetic signal is selected. Linear connections or cubic splines or Bezier splines serve as interpolation rule for connection between consecutive movement sections. Further embodiments include controllers programmed for or containing programming for performing steps of the method embodiments, as well as systems incorporating such controllers.