Embodiments of the present invention generally provide shield electrodes for shielding one or more conductive routing traces from one or more receiver electrodes in an input device comprising a display device integrated with a sensing device to reduce the capacitive coupling between the conductive routing traces and the receiver electrodes. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula or its pharmaceutically acceptable salt. The leaflet structure comprises a plurality of leaflets. The electrical coupling may be capacitive or inductive. The device is robust and easily assembled and has the ability to independently control the three streams involved in making the polymersomes. These compounds are useful as kappa agonists.