A route planning system is provided with various interlinked facilities, including a user IO facility, a route planning facility, a position determination facility, and a destination table facility. Software operative on a centralized server system receives orders from users and search requests for store locations meeting certain proximity criteria. The device may determine, for example, whether the probe is stable, whether it is sealed in the ear canal, whether the resulting volume of the ear canal is acceptable, andor whether the stimuli delivery system is blocked in any way. A partition plate or a support including concavo-convex portions in which plural optical fiber cables can be disposed is disposed inside the gutter or drain pipe 2, or the optical fiber cables are laid in a state where they are passed through a sheath tube or sheath tubes where plural sheath portions are laterally coupled together. The cutting path and bearing path are aligned with each other and correspond to the desired size and contour of the tile. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.