There is provided a charge pump circuit which can prevent EMI noise of a frequency component independent of an operation clock frequency from occurring at the time of a change from a disable state to an enable state. A silicon dioxide comprising layer is formed proximate thereto. The hollow cutter is translatable relative to the needle portion to sever a tissue sample from tissue protruding though the aperture. A light-sensitive device is disposed in the opening to receive light traveling through the optical fiber from the splitter-coupler.