A microcontroller with a mixed analogdigital architecture including multiple digital programmable blocks and multiple analog programmable blocks in a communication array having a programmable interconnect structure. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 andor frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. A process by which APFO may be removed and recovered from water by electrosorption is discovered.