The invention provides a bipolar transistor attaining large MSG and a method of fabricating the same. The first and second shields are configured to make first and second spaces to house the power transmitting and power receiving antennas, respectively. Insulin, delivered transdermally by means of topical application to a portion of skin having wrinkles andor furrows therein, permeates the epidermis and accumulates in the dermis and subcutaneous tissue underlying the portion of skin. The difference data represents a difference between pixel-averaged data and the pixel-edge data.