Disclosed herein are substituted pyrazine compounds and tautomers, stereoisomers, solvates, or pharmaceutically acceptable salts thereof for the treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition, including compounds of formula I:. For example, an article of footwear includes an upper assembly having a first layer coextensive with a second layer. An operation result monitoring processing unit determines whether the operation result information is abnormal, and supplies the result of the determination to a manufacturingusage environment factor classification processing unit. A protection module containing asset lists, calling process identification information, transformation keys, and optionally other information such as transformation algorithms is used in association with the file transformation module.