The present invention relates to pharmaceutical compositions comprising a topoisomerase I inhibitor including, but not limited to, a camptothecin derivative. Other embodiments are described and claimed. The fine powder of the peels of the citrus fruits used in the dyeing is powder having passed a sieve of 140 to 50 mesh. 5-50 microns, opposing front and back substrate surfaces and a series of spaced alternating n-type and p-type thermoelectric legs disposed in parallel arrangement on the front substrate surface. The one of the plurality of 2\xd72 binary patterns corresponds to at least one respective bit of the watermark data when a pixel of the halftoned image data is 50% gray. All of these operations may be accomplished without requiring the driver of the towing vehicle to leave the driving position.