The invention refers to a method and a press tool for manufacturing of a separating disk adapted to be included in a disk package of a centrifugal separator. More particularly, the present invention relates to a synergistic combination of a selective inhibitor of the neuronal norepinephrine transporter and an analgesic agent in the therapeutic management of vertebrate animals, including humans, for producing analgesia or for the prevention or alleviation of pain. For each transaction group, an instruction is or is not issued to each server to change a current value of the maximum permitted local multiplicity for each server to a new value of the maximum permitted local multiplicity.