An apparatus and method of producing methanol includes reacting a heated hydrocarbon-containing gas and an oxygen-containing gas in a reactor; to provide a product stream comprising methanol; and transferring heat from the product stream to the hydrocarbon-containing gas to heat the hydrocarbon containing gas. A first groove and a second groove extend along a longitudinal direction from a base end of the vibrating arm and are formed on at least one of a front surface or a back surface of the vibrating arms. The present invention further includes methods of making and using the solid dose of the invention. Further, because the light guide is a portion of the structure of the knob, the structure of the knob can be simplified from this standpoint as well. The content information relating to tracks in the segment is compared with previous user input to select tracks within the segment to be recorded. The libraries have length and sequence diversities that mimic that found in native human antibodies.