The present invention relates to certain fused pyrazole derivatives of Formula, and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Neighboring shapes are smoothed prior to determining their influence on the fragmentation of the shape of interest, where the amount of smoothing of a neighboring shape increases as the influence of the neighboring shape on the image process of the shape of interest decreases. The detachable drive end mechanism includes a detachable drive end and a collar which engages the retaining structure.