Provided herein are novel sirtuin-modulating compounds of Structural Formula and methods of use thereof. Next, thin transparent film is placed over the teeth to seal the tooth whitener onto the teeth. After cooling, the yarn plug is disentangled to form a crimped yarn, with the latter being wound to a package. For each of the categories there is an allocation register for defining a respective selected proportion of the memory space of the output buffer and structure for accumulating a running total of packet sizes, the total being reduced by the size of each packet in the respective category and leaving the buffer for the port.