A method of selectively blocking a portion of a nerve signal is disclosed. The conduit reamer includes a first cylindrical portion having a first sidewall with a first diameter, and a second cylindrical portion positioned partially within and extending out of the first cylindrical portion. The amplitude component of the transmission signal is low-pass filtered in a low-pass filter configured by filtering parameters selected according to the number of transmission resource blocks allocated to the radio transmitter. The perforation cutter assembly includes first and second rollers with a cutting blade, with a discontinuous edge, and an anvil surface, respectively, to make perforations in the first substrate web. The charge pump circuit further has a first pump capacitor, a second pump capacitor, a first auxiliary capacitor, and a second auxiliary capacitor. The present invention further provides methods of identifying a compound that modulates the expression of a component of a complex described herein, the formation of a complex described herein or the activity of a complex described herein, and methods of preventing, treating, managing or ameliorating a disorder, such as a proliferative disorder, or a symptom thereof utilizing such a compound.