A system and method for automatically generating a data flow diagram in response to a first diagram. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. The direct-lit LED array is disposed between the baseplate and the light guide panel. In another embodiment of the invention, a semiconductor device is formed including a first interconnect structure that extends through a conductive pad and is electrically coupled with the conductive pad while a second interconnect structure is formed through another conductive pad while being electrically isolated therefrom. In the method, the in situ inspection includes illuminating a line of the skin perpendicular to the axial direction and detecting the illuminated line scattered from the skin.