The invention provides methods for treating and preventing a neurodegenerative disease associated with aberrant protein aggregation by modulating the expression andor activity of XBP-1, IRE-1 alpha, andor EDEM. The composition wherein talc has a median particle size of less than 1000 nm further contains a polycarbonate andor polyester-carbonate, and a graft polymer having as graft base a rubber having a glass transition temperature of below about 10 C. The dimension along the x-axis of the top surface of the bottom electrodes has less width than a resolution limit of a photolithography process used to fabricate the phase change memory device.