Trench MOSFETs including active corner regions and a thick insulative layer at the bottom of the trench are disclosed, along with methods of fabricating such MOSFETs. The system includes a winding station having a controllable speed of rotation. The drug delivery element at least partially surrounds the expandable polymeric component. These techniques for non-destructive Seebeck coefficient measurements are simple to operate, and are suitable for bulk samples with a broad range of physical types and shapes. These compounds are useful in the treatment of cell proliferative disorders.