A pinch clamp to restrict flow in a flexible tube or hose is provided. A method is presented which applies a minimum volume of the composition as a coating to the inorganic substrate whereby sufficient heat is added and immediately rinsed with water to achieve complete removal. A switching cycle includes a charging period and a discharging period. The deflection mechanism is configured to cause selected drops to deviate from the first path and begin travelling along a second path. The invention also relates to a method for producing the inducers and to their use as drugs for the regulatory optimization of the paramunizing activities for use in the prophylaxis and therapy of various human and animal dysfunctions.