Compounds having the formula are useful for inhibiting protein tyrosine kinases. One computer-implemented method for determining if actual defects are potentially systematic defects or potentially random defects includes comparing a number of actual defects in a group to a number of randomly generated defects in a group. After the portable patient computing device receives a result of a new gaming session of the patient using a local or remote interactive gaming system, the portable patient computing device either analyzes the newly received result using the identified trend, or passes the newly received result to the remote caregiver computing device for remote analysis, or both. In such case, the ECC controller causes a new ECC syndrome to be generated and stored, and the corresponding flag bit is reset to the first value. Somethings are only too good to be true only when we refuse to make them come true.