A method is provided for manufacturing a three dimensional frame structure that can be used as a core structure in a sandwich construction. The running board includes a housing and a light-producing assembly disposed inside the housing. The deacetylase activity can be measured by a simple procedure according to the present invention. Wherein, the heating and cooling system is substantially shielded from the electromagnetic field by the optimized top piece, and the optimized top piece can substantially be handled by a single person.