Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a topoisomerase inhibitor or an anthracycline, or a combination thereof. The first laser drive field has a frequency approximately equivalent to a transition frequency between a first state and a second state. The oral delivery device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, including a therapeutically effective amount of at least one anti-inflammatory agent, at least one antibacterial agent, or the combination of at least one anti-inflammatory agent and at least one antibacterial agent. The flex edge can deflect back and away from an obstacle to prevent damage to the obstacle. A capsule like device is disposed inside the cylindrical member adjacent the closed end for retaining a substance to be dispensed into a beverage in such bottle.