A compound of the formula I 1wherein R1, R2 and R3 are the same or different and each is hydrogen atom, hydroxy, lower alkyl or aryl, R is a group of the formula 2wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof. Suture packages are located in an interior space of the housing and biased towards a top of the device. In a process in which the intermediate member 14 moves in the axial direction when a solenoid 74 or a solenoid 76 is energized, balls 46 and 48 move in mutually opposite directions in response to a displacement in the axial direction caused by the movement of the intermediate member 14, and the phase between the outer cylinder part 10 and the camshaft 2 is variably adjusted. Other aspects of the technology are also described.