A method and an electronic device for reducing digital image noises are described. In an embodiment, a control instructing section causes a status information generating and sending section to send its own ID information signal and a status information signal indicating its own present operational conditions to the control information terminal via a communication line. A laterally oriented slot is open at a radially perimeter location and configured to receive an o-ring seal via the perimeter location. The quantification of the frequency is one of the standard deviation, the coefficient of variation, the index of dispersion, and the variance. These methods also are useful for isolating substrates for their identification, for the detection of substrates in a sample, and for the discovery and development of ethical drugs.