The present invention relates to methods for inhibiting malignant tumour growth, invasion andor metastasis in a patient, the method comprising suppressing the inhibitory activity of an inhibitor of a protease or of a non-proteolytic matrix-degrading enzyme in malignant tumour tissue or potential malignant tumour tissue. The vibration massage device is further used in conjunction with a fluid filled bladder, where the fluid filled bladder is positioned on top or underneath the transmitting plate for creating increased pressure from the protruding fingertips against the user. In one embodiment, the matchmaker service groups the match requests into matchable sets based on the application for which the requests are received and one or more variables associated with the application.