The present invention refers to the treatment of a rheumatic disease andor osteoarthritis by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof. More specifically, the tucker wheel may engage a gusset within a flap as a carton proceeds downstream within a article grouping and packaging machine. When subsequent route requests contain further information pertaining to the same locations, the navigation server updates the travel time. A sealing member is disposed along the nozzle tube. An example is cited using a bag with flap mounts and equipment which mounts to the flaps using clamps.