The present invention relates to sequence selective compounds for targeting therapeutic or diagnostic groups to polynucleotides. A secondary cooling circuit includes a secondary radiator, an EGR cooler, and a liquidair charge air pre-cooler receiving engine inlet air from a turbocharger compressor. The mutual adhesion strength between the insulating layers through the intermediary of the adhesive layer is 7. The measured BER is compared to a predetermined threshold value to detect a loss-of-signal condition. By homogeneously forming the bearing element from a composite material which includes Teflon, wear of the bearing element will not effect lubrication of the bearing. The center frequency of the first IF frequency-range may be at least 30% to 35% higher than a highest frequency in the receive-frequency range to provide an image frequency far from the highest frequency in the receive-frequency range.