A drug delivery system and methods are provided wherein a therapeuticdiagnostic agent or a component of the immune system is directed to particular cells in a selected organ or a specific site. The CMP process involves the oscillatory and rotational compressional contact between the ABS surface of the slider and a polymerically pre-treated compliant pad that is sprayed by an aqueous alkali lubricating solution having a pH between about 9 and 10. The adhesive pad can be any pad onto which a user can place their fingers to remove lint and debris therefrom, without leaving behind a residue. A plurality of optical fibers may be directed through the passageways of the manifold to produce a three dimensional optical circuit such as a shuffle. a thickening agent to form a polymerizable material, polymerizing said polymerizable material in a mold to form a molded compound. The cover mechanism further comprises a first lifting mechanism connected to the sealing holder, wherein the first lifting mechanism provides a moving direction for the sealing holder along a longitudinal axis of the sealing element relative to the loading platform.