The present invention relates to a process for the production of crystalline particles of a glucagon receptor antagonist compound. At least one polarization switch receives the input optical beam from the optical waveguide. Diagnosis is made as to whether a difference between an echo signal and the medium value signal is more than a positive threshold value or less than a negative threshold value. While this transfer is occurring, the processor is able to carry out other tasks and access the unreserved portion of cache in the normal manner. In certain embodiments, compositions and methods of the invention are used to target polyelectrolyte toxicity to predetermined regions within a subject, while minimizing undesirable toxicity at other regions with the subject.