A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. The active stage may include a Stirling expander, and the passive second and third stages may be pulse tube coolers. An angle adjusting device of the cervical vertebrae orthosis is structured by coaxially pivoting a clutch member with a radial pawl fixed and attached to a thoracic cage body, a lower jaw holding body and an occipital region holding body. A plastic header is molded to encapsulate the adapter, connector block, and bore contact wire and, when solidified, has an undersurface for engagement on the casing and an elongated receptacle aligned with a connector block bore to receive the lead. The first load circuit loads a reference cell coupled to the reference voltage node. The power train includes two composite planetary gear sets and seven engagement elements: two clutches and five brakes.