There is provided an automatic processing apparatus which can protect the secret items of the validator, easily provide a measure for change of bank note and reduce the manufacturing cost. In particular, the methods disclose evaluating levels of characteristic chemokine biomarkers, such as CCL2, CCL3, CCL4, CCL5, CXCL13, CCL17, CCL22, or TNF-alpha to select subjects that would have a greater chance of benefiting from treatment with a PI3K-delta inhibitor. The setting unit is operable to set an alarm mode and an alarm time of the electronic device.