An innovative, low-density, highly-insulating modular panel for use in many applications and industries. In the diagnostic methods of the subject invention, a host derived sample, typically PBMC or a derivative thereof, is assayed for the presence of low molecular weight fragments of RNase L, typically in conjunction with an evaluation of caspase activity. An artificial neural network receives the tire rolling speed estimation, the contact patch length estimation, the amplitude variation within the deformation signal, and the measured inflation pressure of the tire.