A modular knee prosthesis includes a femoral stem having a proximal end portion. OXHS4 gene is cloned using candidate gene screening method. The high power pulsed optical source also includes a first reflective device coupled to a second port of the multi-port optical circulator and a first double-pass optical amplifier coupled at a first end to a third port of the multi-port optical circulator and coupled at a second end to an amplitude modulator. The processor is also configured to publish the converted second portion of the message so as to be viewable in the second format only if the sender has been identified as an authorized sender. A bonus server operates in conjunction with the gaming server to determine when a bonus is to be awarded to one or more players. The first current mirror circuit and the second current mirror circuit supply superimpose an output of the input stage circuit on a current corresponding to the constant current by the floating constant current source to supply to the operation point setting circuit.